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HUMPHREY, J.H. (2015): The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial. Rationale, Design, and Methods. (= Clinical Infectious Diseases, 685/61). URL [Accessed: 01.01.1970]. PDF

Child stunting and anemia are intractable public health problems in developing countries and have profound short- and long-term consequences. The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial is motivated by the premise that environmental enteric dysfunction (EED) is a major underlying cause of both stunting and anemia, that chronic inflammation is the central characteristic of EED mediating these adverse effects, and that EED is primarily caused by high fecal ingestion due to living in conditions of poor water, sanitation, and hygiene (WASH).